Items where Author is "Kyba, Michael"

Bosnakovski, Darko and Kyba, Michael and Toso, Erik and da Silva, Meiri and Sunny, C. and Enner, Elizabeth and Yuan, C. and Walters, M. (2019) A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death. Science Advances.

Lee, JK and Bosnakovski, Darko and Toso, Erik and Dinh, T and Banerjee, S and Bohl, TE and Shi, K and Orellana, K and Kyba, Michael and Aihara, Hideki (2018) Crystal Structure of the Double Homeodomain of DUX4 in Complex with DNA. Cell Reports.

Bosnakovski, Darko and Gearhart , M and Toso, Erik and Ener, Elizabeth and Choi, Si Ho and Kyba, Michael (2018) Low level DUX4 expression disrupts myogenesis through deregulation of myogenic gene expression. Scientific Reports.

Bosnakovski, Darko and Toso, Erik and Hartweck, Lynn M. and Magli, Alessandro and Lee, HA and Thompson, ER and Dandapat, Abhijit and Perlingeiro, Rita C. R. and Kyba, Michael (2017) The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain. Journal of Cell Sciense.

Bosnakovski, Darko and Chan, Sunny and Recht, Olivia and Hartweck, Lynn M. and Gustafson, Collin and Athman, Laura and Lowe, Dawn and Kyba, Michael (2017) Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model. Nature Communications.

Bosnakovski, Darko and Gearhart, Micah and Toso, Erik and Recht, Olivia and Cucak, Anja and Jain, Abhinav and Barton, Michelle and Kyba, Michael (2017) p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy. Disease Models & Mechanisms.

Choi, Si Ho and Gearhart, Micah and Cui, Ziyou and Bosnakovski, Darko and Kim, Minjee and Schennum, Natalie and Kyba, Michael (2016) DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes. Nucleic Acids Research.

Choi, Si Ho and Bosnakovski, Darko and Strasser, JM and Toso, Erik and Walters, Michael and Kyba, Michael (2016) Transcriptional Inhibitors Identified in a 160,000-Compound Small-Molecule DUX4 Viability Screen. Slas Discovery: Advancing Life Sciences R&D, 21 (7). pp. 680-688. ISSN 2472-5560

Dandapat, Abhijit and Bosnakovski, Darko and Hartweck, Lynn M. and Arpke, Robert and Baltgalvis, Kristen and Vang, Derek and Baik, June and Darabi, Radbod and Perlingeiro, Rita C. R. and Hamra, Kent and Gupta, Kapil and Lowe, Dawn and Kyba, Michael (2014) A new mouse model for FSHD. In: FSH Society Facioscapulohumeral Muscular Dystrophy [FSHD] 2014 International Research Consortium & Research Planning Meetings, San Diego Marriott Marquis & Marina.

Dandapat, Abhijit and Bosnakovski, Darko and Hartweck, Lynn M. and Arpke, Robert and Baltgalvis, Kristen and Vang, Derek and Baik, June and Darabi, Radbod and Perlingeiro, Rita C. R. and Hamra, Kent and Gupta, Kapil and Lowe, Dawn and Kyba, Michael (2014) Dominant lethal pathologies in male mice engineered to contain an X-linked DUX4 transgene. Cell Reports, 8. pp. 1484-1496.

Bosnakovski, Darko and Choi, Si Ho and Strasser, Jessica and Toso, Erik and Walters, Michael and Kyba, Michael (2014) High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity. Skelet Muscle.

Dandapat, Abhijit and Hartweck, Lynn M. and Bosnakovski, Darko and Kyba, Michael (2013) Expression of the Human FSHD-Linked DUX4 Gene Induces Neurogenesis During Differentiation of Murine Embryonic Stem Cells. Stem Cells and Development, 22 (17). ISSN 2440-2448

Bosnakovski, Darko and Islam, Shabana and Nandez, Ramiro and Zaidman, Nathan and Struck, Matthew and Dandapat, Abhijit and Kyba, Michael (2012) Maintenance of Human iPS Cells in a Feeder-free Culture System. BD Biosciences.

Iacovino, Michelina and Bosnakovski, Darko and Fey, Holger and Rux, Danielle and Bajwa, Gagan and Mahen, Elisabeth and Mitanoska, Ana and Xu, Zhaohui and Kyba, Michael (2011) Inducible cassette exchange: a rapid and efficient system enabling conditional gene expression in embryonic stem and primary cells. Stem Cells, 29 (10). ISSN 1580–1588

Chen, Steven C. and Frett, Ellie and Marx, Joseph and Bosnakovski, Darko and Reed, Xylena and Kyba, Michael and Kennedy, Brian K. and Feany, Mel B. (2011) Decreased Proliferation Kinetics of Mouse Myoblasts Overexpressing FRG1. Plos One.

Darabi, Radbod and Pan, Weihong and Bosnakovski, Darko and Baik, June and Kyba, Michael and Perlingeiro, Rita C. R. (2011) Functional Myogenic Engraftment from Mouse iPS Cells. Stem Cell Reviews and Reports. pp. 1-10.

Dandapat, Abhijit and Bosnakovski, Darko and Baltgalvis, Kristen and Hartweck, Lynn M. and Lonetree, Cara-lin and Nash, Nardine and Lowe, Dawn and Kyba, Michael (2011) Mouse model to understand the role of Dux4 in FSHD. In: ISSCR 9th Annual Meeting, 15-18 June 2011, Toronto, Ontario, Canada.

Bosnakovski, Darko and Hartweck, Lynn M. and Dandapat, Abhijit and Day, John and Nandez, Ramiro and Kyba, Michael (2010) New cellular and animal models for FSHD. In: FSH Society Facioscapulohumeral Muscular Dystrophy [FSHD] 2010 International Research Consortium & Research Planning Meetings, 21‐22 Oct 2010, Boston, USA.

Bosnakovski, Darko and Daughters, Randy S. and Xu, Zhaohui and Slack, Jonathan M. W. and Kyba, Michael and Bridger, Joanna Mary (2009) Biphasic Myopathic Phenotype of Mouse DUX, an ORF within Conserved FSHD-Related Repeats. Plos One, 4.

Gang, Eun Ji and Darabi, Radbod and Bosnakovski, Darko and Xu, Zhaohui and Kamm, Kristine E. and Kyba, Michael and Perlingeiro, Rita C. R. (2009) Engraftment of mesenchymal stem cells into dystrophin-deficient mice is not accompanied by functional recovery. Experimental Cell Research, 315. pp. 2624-2636.

Bosnakovski, Darko and Nandez, Ramiro and Struck, Matthew and Zaidman, Nathan and Kyba, Michael (2009) Generation of induced pluripotent stem cells from patient-specific FSHD myoblasts. In: 13th Annual Minnesota Muscle Symposium, 9 June 2009, USA.

Kyba, Michael and Bosnakovski, Darko and Dandapat, Abhijit and Darabi, Radbod (2009) Investigating disease mechanisms and cell therapy with pluripotent cells bearing FSHD mutations. In: FSH Society Facioscapulohumeral Muscular Dystrophy [FSHD] 2009 International Research Consortium & Research Planning, 9-10 Nov 2009.

Bosnakovski, Darko and Kyba, Michael (2008) DUX4 in Cells and Mice. In: Facioscapulohumeral Muscular Dystrophy International Research Consortium 2008, 11 Nov 2008, Philadelphia.

Bosnakovski, Darko and Lamb, Sarah and Simsek, Tugba and Xu, Zhaohui and Belayew, Alexandra and Perlingeiro, Rita C. R. and Kyba, Michael (2008) DUX4c, an FSHD candidate gene, interferes with myogenic regulators and abolishes myoblast differentiation. Experimental Neurology, 214. pp. 87-96.

Bosnakovski, Darko and Xu, Zhaohui and Li, Wei and Thet, Suwannee and Cleaver, Ondine and Perlingeiro, Rita C. R. and Kyba, Michael (2008) Prospective Isolation of Skeletal Muscle Stem Cells with a Pax7 Reporter. Stem Cells, 26. pp. 3194-3204.

Tang, Wei and Zeve, Daniel and Suh, Jae Myoung and Bosnakovski, Darko and Kyba, Michael and Hammer, Robert E. and Tallquist, Michelle D. and Graff, Jonathan M. (2008) White Fat Progenitor Cells Reside in the Adipose Vasculature. Science, 322. pp. 583-586.

Bosnakovski, Darko and Xu, Zhaohui and Gang, Eun Ji and Galindo, Cristi L and Liu, Mingju and Simsek, Tugba and Garner, Harold R and Agha-Mohammadi, Siamak and Tassin, Alexandra and Coppee, Frederique and Belayew, Alexandra and Perlingeiro, Rita R and Kyba, Michael (2008) An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies. Embo Journal, 27. pp. 2766-2779.